解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract:BACKGROUND:Cerebral blood flow (CBF) quantitation using technetium-99m hexamethylpropyleneamine oxime (99mTc-HMPAO) generally requires assessment of input function by arterial blood sampling, which would be invasive for small animals. We therefore performed chest dynamic planar imaging, instead of arterial blood sampli...
journal_title:EJNMMI research
pub_type: 杂志文章
doi:10.1186/s13550-018-0375-7
更新日期:2018-03-09 00:00:00
abstract:BACKGROUND:In this work, the in vitro and in vivo stabilities and the pharmacology of HPMA-made homopolymers were studied by means of radiometal-labeled derivatives. Aiming to identify the fewer amount and the optimal DOTA-linker structure that provides quantitative labeling yields, diverse DOTA-linker systems were con...
journal_title:EJNMMI research
pub_type: 杂志文章
doi:10.1186/s13550-018-0372-x
更新日期:2018-02-27 00:00:00
abstract:BACKGROUND:Amino acid co-infusion for renal protection in endoradiotherapy (ERT) applied as prostate-specific membrane antigen (PSMA)-targeted radioligand therapy (RLT) or peptide receptor radionuclide therapy (PRRT) has been shown to cause severe hyperkalemia. The pathophysiology behind the rapid development of hyperk...
journal_title:EJNMMI research
pub_type: 杂志文章
doi:10.1186/s13550-018-0370-z
更新日期:2018-02-27 00:00:00
abstract:BACKGROUND:In vivo determination of regional pulmonary blood flow (PBF) is a valuable tool for the evaluation of many lung diseases. In this study, the use of 68Ga-DOTA PET for the in vivo quantitative determination of regional PBF is proposed. This methodology was implemented and tested in healthy pigs and validated u...
journal_title:EJNMMI research
pub_type: 杂志文章
doi:10.1186/s13550-017-0259-2
更新日期:2017-12-01 00:00:00
abstract:BACKGROUND:Dosimetry in radionuclide therapy has the potential to allow for a treatment tailored to the individual patient. One therapeutic radiopharmaceutical where patient-specific dosimetry is feasible is 177Lu-DOTATATE, used for the treatment of neuroendocrine tumours. The emission of gamma photons by 177Lu allows ...
journal_title:EJNMMI research
pub_type: 杂志文章
doi:10.1186/s13550-017-0262-7
更新日期:2017-12-01 00:00:00
abstract:BACKGROUND:The use of radiolabeled choline as a positron emission tomography (PET) agent for imaging primary tumors in the prostate has been evaluated extensively over the past two decades. There are, however, conflicting reports of its sensitivity and the relationship between choline PET imaging and disease staging is...
journal_title:EJNMMI research
pub_type: 杂志文章
doi:10.1186/s13550-017-0269-0
更新日期:2017-12-01 00:00:00
abstract:BACKGROUND:177Lu-[DOTA0, Tyr3]-octreotate (177Lu-octreotate) is used for treatment of patients with somatostatin receptor (SSTR) expressing neuroendocrine tumors. However, complete tumor remission is rarely seen, and optimization of treatment protocols is needed. In vitro studies have shown that irradiation can up-regu...
journal_title:EJNMMI research
pub_type: 杂志文章
doi:10.1186/s13550-016-0247-y
更新日期:2017-12-01 00:00:00
abstract:BACKGROUND:Molecular breast imaging (MBI) performed with 99mTc sestamibi has been shown to be a valuable technique for the detection of breast cancer. Alternative radiotracers such as 99mTc maraciclatide may offer improved uptake in breast lesions. The purpose of this study was to compare relative performance of 99mTc ...
journal_title:EJNMMI research
pub_type: 杂志文章
doi:10.1186/s13550-017-0255-6
更新日期:2017-12-01 00:00:00
abstract:BACKGROUND:Routine work-up for transarterial radioembolization, based on clinical and laboratory parameters, sometimes fails, resulting in severe hepatotoxicity in up to 5% of patients. Quantitative assessment of the pretreatment liver function and its segmental distribution, using hepatobiliary scintigraphy may improv...
journal_title:EJNMMI research
pub_type: 杂志文章
doi:10.1186/s13550-016-0248-x
更新日期:2017-12-01 00:00:00
abstract::Translocator protein (TSPO) is a biomarker for detecting neuroinflammation by PET. 11C-(R)-PK11195 has been used to image TSPO since the 1980s. Here, we compared the utility of four 11C-labeled ligands-(R)-PK11195, PBR28, DPA-713, and ER176-to quantify TSPO in healthy humans. For all of these ligands, BP ND (specific-...
journal_title:EJNMMI research
pub_type: 信件
doi:10.1186/s13550-017-0334-8
更新日期:2017-10-16 00:00:00
abstract:BACKGROUND:Image-based measurement of absorbed dose of Ra-223 dichloride may be useful in predicting therapeutic outcome in patients with castration-resistant prostate cancer (CRPC). In general, SPECT has been found to be more accurate than planar imaging in terms of lesion-based analysis. The aims of this study were t...
journal_title:EJNMMI research
pub_type: 杂志文章
doi:10.1186/s13550-017-0330-z
更新日期:2017-10-03 00:00:00
abstract:BACKGROUND:PET/MRI can be used for the detection of disease in biochemical recurrence (BCR) patients imaged with 68Ga-PSMA-11 PET. This study was designed to determine the optimal MRI sequences to localize positive findings on 68Ga-PSMA-11 PET of patients with BCR after definitive therapy. Fifty-five consecutive prosta...
journal_title:EJNMMI research
pub_type: 杂志文章
doi:10.1186/s13550-017-0327-7
更新日期:2017-09-19 00:00:00
abstract:BACKGROUND:We investigated the association between physiologic bowel FDG uptake and gut microbiota. FDG uptake in the normal large and small intestine is widely variable both in distribution and intensity. The etiology of physiologic bowel 18F-FDG activity remains unknown. RESULTS:We included 63 healthy male subjects....
journal_title:EJNMMI research
pub_type: 杂志文章
doi:10.1186/s13550-017-0318-8
更新日期:2017-08-31 00:00:00
abstract:BACKGROUND:PET/CT with the radioactively labelled galactose analogue 2-18F-fluoro-2-deoxy-D-galactose (18F-FDGal) can be used to quantify the hepatic metabolic function and visualise regional metabolic heterogeneity. We determined the day-to-day variation in humans with and without liver disease. Furthermore, we examin...
journal_title:EJNMMI research
pub_type: 杂志文章
doi:10.1186/s13550-017-0320-1
更新日期:2017-08-29 00:00:00
abstract:BACKGROUND:Hypoxic tumours exhibit increased resistance to radiation, chemical, and immune therapies. 18F-fluoromisonidazole (FMISO) positron emission tomography (PET) is a non-invasive, quantitative imaging technique used to evaluate the presence and spatial distribution of tumour hypoxia. To facilitate the use of FMI...
journal_title:EJNMMI research
pub_type: 杂志文章
doi:10.1186/s13550-016-0210-y
更新日期:2016-12-01 00:00:00
abstract:BACKGROUND:Assessment of liver function is critical in hepatocellular carcinoma (HCC) patient management. We evaluated parameters of [(99m)Tc] sulfur colloid (SC) SPECT/CT liver uptake for association with clinical measures of liver function and outcome in HCC patients. METHODS:Thirty patients with HCC and variable Ch...
journal_title:EJNMMI research
pub_type: 杂志文章
doi:10.1186/s13550-016-0212-9
更新日期:2016-12-01 00:00:00
abstract:BACKGROUND:We aimed to determine the accuracy of laser Doppler perfusion imaging (LDPI) in an animal model for hind limb ischemia. METHODS:We used a murine (C57Bl/6 mice) ischemic hind limb model in which we compared LDPI with the clinically used (99m)Tc-sestamibi SPECT perfusion imaging (n = 7). In addition, we used ...
journal_title:EJNMMI research
pub_type: 杂志文章
doi:10.1186/s13550-016-0199-2
更新日期:2016-12-01 00:00:00
abstract:BACKGROUND:Biologicals directed against tumour necrosis factor (TNF) have proven their efficacy in the treatment of spondyloarthritis and rheumatoid arthritis. We present a radiolabelling method for certolizumab pegol (CZP), a commercially available humanized Fab'-fragment directed against TNF. A biodistribution and do...
journal_title:EJNMMI research
pub_type: 杂志文章
doi:10.1186/s13550-016-0245-0
更新日期:2016-12-01 00:00:00
abstract:BACKGROUND:The availability of GABAA receptor binding sites in the brain can be assessed by positron emission tomography (PET) using the radioligand, [18F]flumazenil. However, the brain uptake and binding of this PET radioligand are influenced by anesthetic drugs, which are typically needed in preclinical imaging studi...
journal_title:EJNMMI research
pub_type: 杂志文章
doi:10.1186/s13550-016-0235-2
更新日期:2016-12-01 00:00:00
abstract:BACKGROUND:In PET/MRI, linear photon attenuation coefficients for attenuation correction (AC) cannot be directly derived, and cortical bone is, so far, usually not considered. This results in an underestimation of the average PET signal in PET/MRI. Recently introduced MR-AC methods predicting bone information from anat...
journal_title:EJNMMI research
pub_type: 杂志文章
doi:10.1186/s13550-016-0200-0
更新日期:2016-12-01 00:00:00
abstract:BACKGROUND:In preclinical positron emission tomography (PET) studies an anaesthetic is used to ensure that the animal does not move during the scan. However, anaesthesia may have confounding effects on the drug or tracer kinetics under study, and the nature of these effects is usually not known. METHOD:We have impleme...
journal_title:EJNMMI research
pub_type: 杂志文章
doi:10.1186/s13550-016-0242-3
更新日期:2016-12-01 00:00:00
abstract:BACKGROUND:We quantified myocardial blood flow with (82)Rb PET using parameters of the generalized Renkin-Crone model estimated from (82)Rb and (15)O-water images reconstructed with time-of-flight and point spread function modeling. Previous estimates of rubidium extraction have used older-generation scanners without t...
journal_title:EJNMMI research
pub_type: 杂志文章
doi:10.1186/s13550-016-0215-6
更新日期:2016-12-01 00:00:00
abstract:BACKGROUND:Targeted alpha therapy (TAT) offers advantages over current β-emitting conjugates for peptide receptor radionuclide therapy (PRRT) of neuroendocrine tumors. PRRT with 177Lu-DOTATATE or 90Y-DOTATOC has shown dose-limiting nephrotoxicity due to radiopeptide retention in the proximal tubules. Pharmacological pr...
journal_title:EJNMMI research
pub_type: 杂志文章
doi:10.1186/s13550-016-0240-5
更新日期:2016-12-01 00:00:00
abstract:BACKGROUND:Depression in patients with brain tumors is associated with impaired quality of life and shorter survival. Altered metabolism of tryptophan to serotonin and kynurenine metabolites may play a role in tumor-associated depression. Our recent studies with alpha[(11)C]methyl-L-tryptophan (AMT)-PET in brain tumor ...
journal_title:EJNMMI research
pub_type: 杂志文章
doi:10.1186/s13550-015-0136-9
更新日期:2015-12-01 00:00:00
abstract:BACKGROUND:Macrophages represent a critical cell type in host defense, development and homeostasis. The ability to image non-invasively pro-inflammatory macrophage infiltrate into a transplanted organ may provide an additional tool for the monitoring of the immune response of the recipient against the donor graft. We t...
journal_title:EJNMMI research
pub_type: 杂志文章
doi:10.1186/s13550-015-0146-7
更新日期:2015-12-01 00:00:00
abstract:BACKGROUND:Tenascin-C (TNC), an extracellular matrix glycoprotein, is expressed transiently in distinct areas in association with active tissue remodeling. This study aimed to explore how ischemic postconditioning (PC) affects myocardial expression of TNC and ventricular remodeling using (125)I-labeled anti-TNC antibod...
journal_title:EJNMMI research
pub_type: 杂志文章
doi:10.1186/s13550-015-0100-8
更新日期:2015-04-02 00:00:00
abstract:BACKGROUND:Tyrosine kinase inhibitors (TKIs) have experienced a tremendous boost in the last decade, where more than 15 small molecule TKIs have been approved by the FDA. Unfortunately, despite their promising clinical successes, a large portion of patients remain unresponsive to these targeted drugs. For non-small cel...
journal_title:EJNMMI research
pub_type: 杂志文章
doi:10.1186/s13550-015-0088-0
更新日期:2015-03-20 00:00:00
abstract:BACKGROUND:Non-small cell lung carcinoma (NSCLC) represents approximately 80% of lung cancer cases, and over 60% of these tumors express the epidermal growth factor receptor (EGFR). Activating mutations in the tyrosine kinase (TK) domain of the EGFR are detected in 10% to 30% of NSCLC patients, and evidence of their pr...
journal_title:EJNMMI research
pub_type: 杂志文章
doi:10.1186/s13550-014-0080-0
更新日期:2015-02-12 00:00:00
abstract:BACKGROUND:Peptide receptor radionuclide therapy (PRRT) is applied in patients with advanced neuroendocrine tumors. Co-infused amino acids (AA) should prevent nephrotoxicity. The aims of this study were to correlate the incidence of AA-induced hyperkalemia (HK) (≥5.0 mmol/l) and to identify predictors of AA-induced sev...
journal_title:EJNMMI research
pub_type: 杂志文章
doi:10.1186/s13550-014-0074-y
更新日期:2014-12-24 00:00:00
abstract:BACKGROUND:Glioblastoma, the most frequent and aggressive of all astrocytomas, presents a clear predominance in male humans, but the assessment of sexual differences in its tumourigenesis and growth has received little attention so far. In this study, we aim to identify gender-dependent surrogate markers in an animal m...
journal_title:EJNMMI research
pub_type: 杂志文章
doi:10.1186/s13550-014-0044-4
更新日期:2014-12-01 00:00:00
abstract:BACKGROUND:The kidneys are regarded as one of the main dose-limiting organs in the treatment of neuroendocrine tumours with (177)Lu-[DOTA(0), Tyr(3)]-octreotate ((177)Lu-octreotate), despite the successful use of kidney uptake blocking agents such as lysine and arginine. To avoid renal toxicity but still give each pati...
journal_title:EJNMMI research
pub_type: 杂志文章
doi:10.1186/s13550-014-0059-x
更新日期:2014-12-01 00:00:00
abstract:BACKGROUND:Hepatobiliary scintigraphy using (99m)Tc-mebrofenin has been used as an investigation to study liver function after liver transplantation (LTx). Hepatic extraction fraction (HEF) is a measurement of the hepatic extraction efficiency and hepatic extraction rate. With the purpose of evaluating a possible diver...
journal_title:EJNMMI research
pub_type: 杂志文章
doi:10.1186/s13550-014-0073-z
更新日期:2014-12-01 00:00:00
abstract:BACKGROUND:The biology of the vulnerable plaque includes increased inflammation and rapid growth of vasa vasorum, processes that are associated with enhanced vascular endothelial growth factor (VEGF)/ imaging receptors for VEGF (VEGFR) signaling and are accelerated in diabetes. This study was designed to test the hypot...
journal_title:EJNMMI research
pub_type: 杂志文章
doi:10.1186/s13550-014-0041-7
更新日期:2014-12-01 00:00:00
abstract:BACKGROUND:Bone Scan Index (BSI) is a quantitative measurement of tumour burden in the skeleton calculated from bone scan images. When analysed at the time of diagnosis, it has been shown to provide prognostic information on survival in men with metastatic prostate cancer (PCa). In this study, we evaluated the prognost...
journal_title:EJNMMI research
pub_type: 杂志文章
doi:10.1186/s13550-014-0058-y
更新日期:2014-10-17 00:00:00
abstract:BACKGROUND:To combine the sensitivity of bioluminescent imaging (BLI) with the 3D and quantitative properties of pinhole single-photon emission computed tomography (SPECT)/micro-computed tomography (CT) (phSPECT/micro-CT), we generated stable cell lines that express a yellow-fluorescent protein (YFP) and Gaussia lucife...
journal_title:EJNMMI research
pub_type: 杂志文章
doi:10.1186/s13550-014-0032-8
更新日期:2014-06-26 00:00:00
abstract:BACKGROUND:Previously, we reported on the unexpected development of distant metastases in the subcutaneous rat pancreas CA20948 tumor model after 4.5 weeks of treatment with RAD001-only or in combination with [(177)Lu-DOTA(0),Tyr(3)]octreotate ((177)Lu-DOTATATE) (Cancer Res. 73:12-8, 2013). Moreover, the combination th...
journal_title:EJNMMI research
pub_type: 杂志文章
doi:10.1186/s13550-014-0021-y
更新日期:2014-05-30 00:00:00
abstract:BACKGROUND:The purpose of this study was to assess the relationship of CT-perfusion (CTP), 18F-FDG-PET/CT and histological parameters, and the possible added value of CTP to FDG-PET/CT in the initial staging of lung cancer. METHODS:Fifty-four consecutive patients (median age 65 years, 15 females, 39 males) with suspec...
journal_title:EJNMMI research
pub_type: 杂志文章
doi:10.1186/2191-219X-4-6
更新日期:2014-01-22 00:00:00
abstract:BACKGROUND:F-fluorodeoxyglucose (FDG) positron emission tomography (PET) is a promising modality for detecting active lesions of cardiac sarcoidosis (CS). However, determining whether 18F-FDG uptake in the myocardium is physiological is challenging due to metabolic shift in myocardial cells. Although methods for inhibi...
journal_title:EJNMMI research
pub_type: 杂志文章
doi:10.1186/2191-219X-4-1
更新日期:2014-01-02 00:00:00
abstract:BACKGROUND:Fluorine-18 fluoroethoxybenzovesamicol ([18F]FEOBV) is a radioligand for the selective imaging of the vesicular acetylcholine transporter with positron emission tomography (PET). The current study demonstrates that pathological cortical cholinergic deafferentation can be quantified in vivo with [18F]FEOBV PE...
journal_title:EJNMMI research
pub_type: 杂志文章
doi:10.1186/2191-219X-3-70
更新日期:2013-10-09 00:00:00
abstract:BACKGROUND:[18 F]fluorodopa (FDOPA) positron emission tomography (PET) allows assessment of levodopa (LDOPA) metabolism and is widely used to study Parkinson's disease. We examined how [18 F]FDOPA PET-derived kinetic parameters relate the dopamine (DA) and DA metabolite content of extracellular fluid measured by microd...
journal_title:EJNMMI research
pub_type: 杂志文章
doi:10.1186/2191-219X-3-69
更新日期:2013-10-02 00:00:00